Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31087734 | 0.84 | SMN1; SMN2 (0.54) | LCKHSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6057496 | 0.83 | NPC1 (0.73) | LCKFYNSRCHSD17B10SMN1; SMN2 | |
| SCHEMBL6058154 | 0.82 | DYRK1A (0.77) | LCKHSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4746047 | 0.82 | ABL1 (0.70) | LCKHSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6057785 | 0.82 | LCK (1.00) | LCKFYNSRC | |
| SCHEMBL6057851 | 0.82 | LCK (1.00) | LCKFYNSRC | |
| SCHEMBL558047 | 0.81 | LCK (0.69) | LCKHSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2733651 | 0.81 | RAB9A (0.70) | HSD17B10SMN1; SMN2NPC1RAB9ADYRK1A | |
| SCHEMBL6058264 | 0.81 | LCK (0.89) | LCKFYNSRC | |
| SCHEMBL6057822 | 0.80 | LCK (0.85) | LCKFYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |
| EP-1037632-B1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2006-01-11 | — | — | EP | disclosed |
| US-6825355-B2 | FOR THERAPY OF IMMUNOLOGIC DISORDERS SUCH AS TRANSPLANT REJECTION, RHEUMATOID ARTHRITIS. MULTIPLE SCLEROSIS, INFLAMMATORY BOWEL DISEASE, LUPUS, GRAFT VS. HOST DISEASE | BRISTOL-MYERS SQUIBB CO. | 2004-11-30 | — | — | US | disclosed |