Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748992 | 1.00 | PPM1D (0.38) | PPM1DSMN1; SMN2CHRNB2CHRNA4BTK | |
| SCHEMBL4748991 | 1.00 | PPM1D (0.38) | PPM1DSMN1; SMN2CHRNB2CHRNA4BTK | |
| SCHEMBL19148890 | 0.91 | SMN1; SMN2 (0.36) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL22357286 | 0.91 | SMN1; SMN2 (0.36) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL16167661 | 0.91 | SMN1; SMN2 (0.36) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL1498724 | 0.85 | CHRNB2 (0.42) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL19149236 | 0.85 | CHRNB2 (0.42) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL1498725 | 0.85 | CHRNB2 (0.42) | PPM1DSMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4922240 | 0.84 | BTK (0.44) | PPM1DBTK | |
| SCHEMBL4922245 | 0.84 | BTK (0.44) | PPM1DBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119715-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |