SCHEMBL4749134

SCHEMBL4749134

NC(Cc1ccccc1C(F)(F)F)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.51
SLC6A4 P31645 1/20 0.51
IDO1 P14902 2/20 0.49
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
ATM Q13315 1/20 0.45
GNRHR P30968 1/20 0.43
PPARG P37231 2/20 0.43
PPARA Q07869 1/20 0.43
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42
GRIN3A Q8TCU5 1/20 0.42
TACR1 P25103 2/20 0.42
CACNA1F O60840 1/20 0.42
CACNA1D Q01668 1/20 0.42
CACNA1S Q13698 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12706136 0.84 IDO1 (0.50) SLC6A2SLC6A4IDO1KDM4EALDH1A1
SCHEMBL29049552 0.81 IDO1 (0.55) SLC6A2SLC6A4IDO1KDM4EALDH1A1
SCHEMBL7011989 0.79 SLC6A2 (0.51) SLC6A2SLC6A4IDO1KDM4EALDH1A1
SCHEMBL4669556 0.78 IDO1 (0.52) SLC6A2SLC6A4IDO1DPP4DPP7
SCHEMBL268390 0.78 IDO1 (0.52) SLC6A2SLC6A4IDO1DPP4DPP7
SCHEMBL3813108 0.78 IDO1 (0.52) SLC6A2SLC6A4IDO1DPP4DPP7
SCHEMBL15229335 0.77 TACR1 (0.36) SLC6A2SLC6A4IDO1GNRHRGRIN2D
SCHEMBL4708284 0.76 IDO1 (0.50) SLC6A2SLC6A4IDO1KDM4EALDH1A1
SCHEMBL15827644 0.76 IDO1 (0.50) SLC6A2SLC6A4IDO1KDM4EALDH1A1
SCHEMBL503201 0.76 PPARG (0.53) IDO1KDM4EPPARGPPARADPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008123821-A1 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS ALBIREO AB (SE) 2008-10-16 WO claimed
WO-2008123821-A1 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS ALBIREO AB (SE) 2008-10-16 WO disclosed
WO-2008123821-A1 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS ALBIREO AB (SE) 2008-10-16 WO disclosed