Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751345 | 1.00 | MC4R (0.40) | MC4RRBP4KDM2BNPC1TNF | |
| SCHEMBL4749188 | 1.00 | MC4R (0.40) | MC4RRBP4KDM2BNPC1TNF | |
| SCHEMBL4794920 | 0.92 | MC4R (0.44) | MC4RRBP4EGFRITKMEN1 | |
| SCHEMBL4026512 | 0.89 | NPC1 (0.41) | MC4RRBP4KDM2BNPC1TNF | |
| SCHEMBL4751347 | 0.88 | MC4R (0.44) | MC4RRBP4MEN1KMT2A | |
| SCHEMBL4779390 | 0.87 | MC4R (0.43) | MC4RRBP4KDM2B | |
| SCHEMBL4027949 | 0.87 | KDM2B (0.34) | MC4RKDM2BMGLLKMT2A | |
| SCHEMBL4779145 | 0.86 | MC4R (0.40) | MC4RRBP4KDM2BNPC1TNF | |
| SCHEMBL4779138 | 0.86 | MC4R (0.40) | MC4RRBP4KDM2BNPC1TNF | |
| SCHEMBL4749130 | 0.85 | MC4R (0.44) | MC4RRBP4KDM2BEGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |