Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779138 | 1.00 | MC4R (0.40) | MC4RNPC1TNFRAB9ANOD1 | |
| SCHEMBL4026512 | 0.96 | NPC1 (0.41) | MC4RNPC1TNFRAB9ANOD1 | |
| SCHEMBL4751807 | 0.92 | MC4R (0.42) | MC4RNPC1NTRK1F10KDM4E | |
| SCHEMBL4019468 | 0.92 | MC4R (0.42) | MC4RNPC1NTRK1F10KDM4E | |
| SCHEMBL4019465 | 0.92 | MC4R (0.42) | MC4RNPC1NTRK1F10KDM4E | |
| SCHEMBL4021139 | 0.91 | KDM2B (0.43) | MC4RNPC1TNFRAB9ANOD1 | |
| SCHEMBL4751303 | 0.90 | KDM2B (0.33) | MC4RNTRK1KDM2BKDM4E | |
| SCHEMBL4780053 | 0.89 | MC4R (0.44) | MC4RNPC1NTRK1F10KDM4E | |
| SCHEMBL4021775 | 0.87 | NPC1 (0.35) | MC4RNPC1TNFRAB9ANOD1 | |
| SCHEMBL4749418 | 0.86 | KDM2B (0.33) | MC4RNPC1TNFRAB9ANOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |