Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068685 | 0.92 | JAK2 (0.41) | JAK2TYK2ALDH1A1HPGDKDM4E | |
| SCHEMBL4064392 | 0.87 | CD38 (0.44) | JAK2TYK2ALDH1A1HPGDKDM4E | |
| SCHEMBL4067001 | 0.87 | JAK2 (0.41) | JAK2TYK2ALDH1A1HPGDKDM4E | |
| SCHEMBL4071782 | 0.84 | HRH1 (0.49) | ALDH1A1HPGDKDM4ENPSR1L3MBTL1 | |
| SCHEMBL4749294 | 0.82 | PTGDR (0.46) | ALDH1A1APPMEN1KMT2ANPC1 | |
| SCHEMBL4467820 | 0.81 | TDP1 (0.40) | JAK2TYK2NPC1PTGDR | |
| SCHEMBL4069309 | 0.74 | RECQL (0.45) | ALDH1A1HPGDKDM4EL3MBTL1MEN1 | |
| SCHEMBL4251335 | 0.69 | KCNH2 (0.49) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL4749132 | 0.69 | MAOA (0.37) | KDM4EKMT2AGAAHTT | |
| SCHEMBL4746992 | 0.69 | MAOA (0.34) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123756-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |