Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749236 | 0.92 | CHRM1 (0.66) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4811291 | 0.88 | CHRM4 (0.85) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL14042965 | 0.88 | CHRM4 (0.85) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4811274 | 0.88 | CHRM4 (0.85) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4815709 | 0.87 | CHRM4 (0.84) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4789015 | 0.87 | CHRM4 (0.84) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL4789013 | 0.87 | CHRM4 (0.84) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL4648728 | 0.82 | CHRM1 (0.66) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL14944089 | 0.80 | CHRM4 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL603268 | 0.80 | CHRM4 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119721-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119721-A1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |