Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylamine SCHEMBL9591137 | 0.97 | MTNR1A (0.58) | MTNR1AMTNR1BDHODHADRA1ATAAR1 | |
| SCHEMBL29594789 | 0.87 | HTR2A (0.68) | MTNR1AMTNR1BHTR2A | |
| SCHEMBL124465 | 0.87 | HTR2A (0.68) | MTNR1AMTNR1BHTR2A | |
| SCHEMBL15345391 | 0.87 | MTNR1A (0.56) | MTNR1AMTNR1BSIGMAR1 | |
| Bromide SCHEMBL15661932 | 0.86 | HTR2A (0.67) | MTNR1AMTNR1BHTR2A | |
| Hydrochloric Acid SCHEMBL577758 | 0.86 | HTR2A (0.67) | MTNR1AMTNR1BHTR2A | |
| Hydrochloric Acid SCHEMBL29421606 | 0.86 | HTR2A (0.67) | MTNR1AMTNR1BHTR2A | |
| SCHEMBL7193761 | 0.84 | MTNR1A (0.64) | MTNR1AMTNR1BDHODHHTR2ASIGMAR1 | |
| SCHEMBL27626620 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BHTR2ASIGMAR1 | |
| SCHEMBL20562784 | 0.82 | TAAR1 (0.51) | ADRA1ATAAR1HTR2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141033-A1 | SUBSTITUTED NAPHTHALENES | AUSPEX PHARMACEUTICALS INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |
| US-5449689-A | Treating melatoninergic system disorders | ADIR ET COMPAGNIE (FR) | 1995-09-12 | — | — | US | disclosed |
| US-5449690-A | Antihypercholesterol anf melatonin antagonist | ADIR ET COMPAGNIE (FR) | 1995-09-12 | — | — | US | disclosed |
| EP-0530087-B1 | Naphthylethylurea and naphthylethylthiourea compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-05-03 | — | — | EP | disclosed |
| US-5389683-A | Useful in treating or preventing a disorder of the melatoninergic system | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385944-A | Naphthylethylureas and naphthylethylthioureas | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5318994-A | Treating melatoninergic disorders | ADIR ET COMPAGNIE (FR) | 1994-06-07 | — | — | US | disclosed |
| US-5225442-A | Melatoninergic disorders | ADIR ET COMPAGNIE (FR) | 1993-07-06 | — | — | US | disclosed |
| EP-0447285-B1 | NAPHTHALENE DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0530087-A1 | Naphthylethylurea and naphthylethylthiourea compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-03-03 | — | — | EP | disclosed |
| EP-0447285-A1 | Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-09-18 | — | — | EP | disclosed |
| US-4327022-A | Heterocyclic alkyl naphthols | STERLING DRUG INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-3992384-A | NON-ESTROGENIC ANTIFERTILITY AGENTS | SANDOZ, INC. (US) | 1976-11-16 | — | — | US | disclosed |