Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | GRM8 | O00222 | 1/20 | 0.58 |
| ▸ | GRM6 | O15303 | 1/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.58 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.58 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6668644 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL577728 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6672058 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL424415 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578155 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6803653 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL573880 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL2582854 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578156 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL3338199 | 0.98 | GSR (0.56) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1207881-A1 | PHARMACEUTICAL AGENT COMPRISING A BENZAMIDE DERIVATIVE AS ACTIVE INGREDIENT | Schering Aktiengesellschaft (DE) | 2002-05-29 | — | — | EP | claimed |
| WO-2001012193-A1 | PHARMACEUTICAL AGENT COMPRISING A BENZAMIDE DERIVATIVE AS ACTIVE INGREDIENT | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-02-22 | — | — | WO | claimed |
| WO-2020250966-A1 | EMULSION COMPOSITION | 花王株式会社 | 2020-12-17 | — | — | WO | disclosed |
| WO-2008120070-A2 | 2(HYDROXYETHYL)TRIMETHYLAMMONIUM THIOCTATE (CHOLINE THIOCTATE) DISPLAYING HEPATOPROTECTIVE, HYPOAMMONIEMIC AND DETOXIC ACTION, A METHOD FOR ITS PRODUCTION AND A PHARMACEUTICAL COMPOSITION BASED THEREON | AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU «GALYCHFARM» (UA) | 2008-10-09 | — | — | WO | disclosed |
| EP-1207881-A1 | PHARMACEUTICAL AGENT COMPRISING A BENZAMIDE DERIVATIVE AS ACTIVE INGREDIENT | Schering Aktiengesellschaft (DE) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001012193-A1 | PHARMACEUTICAL AGENT COMPRISING A BENZAMIDE DERIVATIVE AS ACTIVE INGREDIENT | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-02-22 | — | — | WO | disclosed |