Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | GRM8 | O00222 | 1/20 | 0.58 |
| ▸ | GRM6 | O15303 | 1/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.58 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.58 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6668644 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6672058 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL424415 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL4749671 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578155 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL6803653 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL573880 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL2582854 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL578156 | 1.00 | GSR (0.58) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Arginine SCHEMBL3338199 | 0.98 | GSR (0.56) | GSRCYP1A2GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689101-B | Compositions for treating disorders | 克雷森多生物制剂有限公司 | 2023-04-28 | — | — | CN | claimed |
| US-11083759-B2 | Oral microbiota transformation for the relief of immune system associated inflammations | KNOZE JR. CORPORATION (US) | 2021-08-10 | — | — | US | claimed |
| US-20190343899-A1 | Oral Microbiota Transformation for the Relief of Immune System Associated Inflammations | KNOZE JR. CORPORATION | 2019-11-14 | — | — | US | claimed |
| US-10471033-B2 | Oral microbiota promotion for immune system associated inflammations | KNOZE JR. CORPORATION (US) | 2019-11-12 | — | — | US | claimed |
| US-20190083435-A1 | Oral Microbiota Promotion for Immune System Associated Inflammations | KNOZE JR. CORPORATION | 2019-03-21 | — | — | US | claimed |
| US-9050365-B2 | Transdermal delivery of beneficial substances effected by a hostile biophysical environment | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2015-06-09 | — | — | US | claimed |
| US-20150080470-A1 | TRANSDERMAL DELIVERY OF BENEFICIAL SUBSTANCES EFFECTED BY A HOSTILE BIOPHYSICAL ENVIRONMENT | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2015-03-19 | — | — | US | claimed |
| US-20150011570-A1 | TRANSDERMAL DELIVERY OF BENEFICIAL SUBSTANCES EFFECTED BY A HOSTILE BIOPHYSICAL ENVIRONMENT | STRATEGIC SCIENCE & TECHNOLOGIES, LLC (US) | 2015-01-08 | — | — | US | claimed |
| EP-1867713-B1 | METHOD OF IMPROVING STORAGE STABILITY OF DRIED MICROORGANISMS | KYOWA HAKKO BIO CO LTD (JP) | 2011-08-24 | — | — | EP | claimed |
| US-20110117194-A1 | PHARMACEUTICAL FORMULATION CONTAINING ANGIOTENSIN-II RECEPTOR BLOCKER | HANALL BIOPHARMA CO., LTD. (KR) | 2011-05-19 | — | — | US | claimed |
| EP-1164848-A4 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING SEXUAL DYSFUNCTIONS | NITROMED INC (US) | 2002-06-05 | — | — | EP | claimed |
| US-20020041903-A1 | TOPICAL DELIVERY OF ARGININE OF CAUSE BENEFICIAL EFFECTS | STRATEGIC SCIENCE & TECHNOLOGIES, LLC. | 2002-04-11 | — | — | US | claimed |
| EP-1164848-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING SEXUAL DYSFUNCTIONS | Nitromed, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| US-6323211-B1 | Compositions and methods for treating sexual dysfunctions | NITROMED, INC. | 2001-11-27 | — | — | US | claimed |
| US-20010002405-A1 | Topical and oral delivery of arginine to cause beneficial effects | STRATEGIC SCIENCE & TECHNOLOGIES, LLC | 2001-05-31 | — | — | US | claimed |
| US-6207713-B1 | Topical and oral delivery of arginine to cause beneficial effects | STRATEGIC SCIENCE & TECHNOLOGIES, LLC | 2001-03-27 | — | — | US | claimed |
| WO-2000059304-A1 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING SEXUAL DYSFUNCTIONS | NITROMED, INC. (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1041880-A1 | A DELIVERY OF ARGININE TO CAUSE BENEFICIAL EFFECTS | Strategic Science & Technologies, Inc. (US) | 2000-10-11 | — | — | EP | claimed |
| WO-2000054773-A1 | DOPAMINE AGONISTS IN COMBINATION WITH NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| WO-1999013717-A1 | A DELIVERY OF ARGININE TO CAUSE BENEFICIAL EFFECTS | STRATEGIC SCIENCE & TECHNOLOGIES, INC. (US) | 1999-03-25 | — | — | WO | claimed |