Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 9/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.65 |
| ▸ | MEN1 | O00255 | 12/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420213 | 0.82 | PARP1 (0.64) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL4420218 | 0.82 | PARP1 (0.64) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1822161 | 0.81 | KMT2A (0.73) | MAPTLMNASMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL3621179 | 0.81 | PARP1 (0.84) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL3621177 | 0.81 | PARP1 (0.84) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL2020280 | 0.80 | ABL1 (0.73) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL16607163 | 0.80 | ALDH1A1 (0.79) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL4747433 | 0.80 | PARP1 (0.78) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL4747429 | 0.80 | PARP1 (0.78) | PARP1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL4747427 | 0.80 | PARP1 (0.78) | PARP1MAPTLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |