Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.64 |
| ▸ | CSF1R | P07333 | 5/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746797 | 0.93 | LCK (0.64) | BRAFCSF1RKITLCK | |
| SCHEMBL14042457 | 0.93 | BRAF (0.61) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042258 | 0.92 | BRAF (0.58) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042245 | 0.91 | BRAF (0.57) | BRAFCSF1RKITMAPK14RAF1 | |
| SCHEMBL14042250 | 0.91 | BRAF (0.59) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042725 | 0.91 | BRAF (0.57) | BRAFCSF1RKITLCKMEN1 | |
| SCHEMBL14042641 | 0.91 | BRAF (0.57) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042437 | 0.91 | BRAF (0.67) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042704 | 0.90 | BRAF (0.64) | BRAFCSF1RKITLCKSRC | |
| SCHEMBL14042465 | 0.90 | BRAF (0.57) | BRAFCSF1RKITLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |