Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | BRAF | P15056 | 12/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968714 | 0.90 | MAPK14 (0.49) | MAPK14BRAFEGFR | |
| SCHEMBL4750107 | 0.85 | BRAF (0.66) | BRAF | |
| SCHEMBL4967010 | 0.79 | MAPK14 (0.48) | MAPK14BRAFEGFRKDR | |
| SCHEMBL4967069 | 0.79 | BRAF (0.62) | MAPK14BRAF | |
| SCHEMBL4746679 | 0.78 | BRAF (0.71) | MAPK14BRAF | |
| SCHEMBL29459596 | 0.78 | BRAF (0.71) | MAPK14BRAF | |
| SCHEMBL5000815 | 0.76 | BRAF (0.63) | BRAF | |
| SCHEMBL5004339 | 0.76 | BRAF (0.62) | BRAF | |
| SCHEMBL4750146 | 0.75 | BRAF (0.69) | MAPK14BRAFKDR | |
| SCHEMBL19462171 | 0.75 | BRAF (0.69) | MAPK14BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | claimed |