Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788091 | 0.84 | BRAF (0.51) | MAPK14CSF1RAURKBKDRBRAF | |
| SCHEMBL4750108 | 0.79 | MAPK14 (0.54) | MAPK14KDRBRAFEGFR | |
| SCHEMBL4749292 | 0.76 | BRAF (0.58) | MAPK14BRAF | |
| SCHEMBL4746679 | 0.75 | BRAF (0.71) | MAPK14BRAF | |
| SCHEMBL29459596 | 0.75 | BRAF (0.71) | MAPK14BRAF | |
| SCHEMBL4968714 | 0.75 | MAPK14 (0.49) | MAPK14AURKBBRAFEGFRAURKA | |
| SCHEMBL4747084 | 0.74 | BRAF (0.57) | MAPK14BRAF | |
| SCHEMBL4750071 | 0.72 | BRAF (0.57) | MAPK14BRAF | |
| SCHEMBL4750107 | 0.72 | BRAF (0.66) | BRAF | |
| SCHEMBL4749632 | 0.71 | BRAF (0.59) | MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966159-A2 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | claimed |
| WO-2007071963-A2 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | claimed |