Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 18/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692932 | 0.83 | AURKA (0.72) | AURKAABL1 | |
| SCHEMBL3887141 | 0.78 | AURKA (0.78) | AURKA | |
| SCHEMBL4694476 | 0.73 | AURKA (0.75) | AURKA | |
| SCHEMBL3879279 | 0.71 | AURKA (1.00) | AURKA | |
| Trifluoroacetic Acid SCHEMBL3881545 | 0.70 | AURKA (0.70) | AURKA | |
| SCHEMBL3883428 | 0.70 | AURKA (0.77) | AURKA | |
| SCHEMBL3882182 | 0.69 | AURKA (0.79) | AURKA | |
| SCHEMBL3887853 | 0.68 | AURKA (0.81) | AURKA | |
| SCHEMBL3885581 | 0.67 | AURKA (0.77) | AURKA | |
| SCHEMBL3891045 | 0.67 | AURKA (1.00) | AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534716-B1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-04-23 | — | — | EP | claimed |