Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355279 | 0.84 | HSP90AB1 (0.56) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL7705078 | 0.84 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL7705102 | 0.84 | TSHR (0.61) | MEN1KMT2ALMNAMAPTABCB1 | |
| SCHEMBL7711004 | 0.84 | MAPT (0.57) | MEN1KMT2ALMNAMAPTABCB1 | |
| Hydrochloric Acid SCHEMBL7711666 | 0.83 | MEN1 (0.63) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7711457 | 0.83 | MAPT (0.58) | MEN1KMT2ALMNAMAPTABCB1 | |
| SCHEMBL7600203 | 0.82 | KMT2A (1.00) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL4753120 | 0.81 | LMNA (0.74) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL7708508 | 0.81 | MEN1 (0.81) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL9410198 | 0.81 | MAPT (0.82) | MEN1KMT2ALMNAMAPTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |