Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298203 | 0.76 | CHRM2 (0.79) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7336794 | 0.73 | MEN1 (0.63) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL10132281 | 0.72 | MAPK1 (0.51) | SMN1; SMN2LMNAMEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL7328249 | 0.71 | APOBEC3A (0.57) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL8989176 | 0.71 | CHRM2 (0.55) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL30573473 | 0.71 | CHRM2 (0.70) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL20595548 | 0.71 | CHRM2 (0.70) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL5320057 | 0.71 | CHRM2 (0.65) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7333899 | 0.71 | APOBEC3A (0.56) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 | |
| SCHEMBL8104266 | 0.70 | CHRM2 (0.68) | SMN1; SMN2LMNACHRM2OPRK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |