Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7333899 | 0.99 | APOBEC3A (0.56) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL7334983 | 0.92 | MEN1 (0.60) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL8989118 | 0.91 | ALDH1A1 (0.63) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7326029 | 0.91 | MEN1 (0.58) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7328249 | 0.90 | APOBEC3A (0.57) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7328045 | 0.90 | LMNA (0.64) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7336379 | 0.87 | APOBEC3A (0.51) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7356889 | 0.85 | APOBEC3A (0.52) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7336794 | 0.85 | MEN1 (0.63) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL7335009 | 0.84 | MEN1 (0.58) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | claimed |
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |