Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29209082 | 0.81 | BRD4 (0.42) | TAS1R3TAS1R1TAS1R2PIK3CDPIK3R1 | |
| SCHEMBL31543989 | 0.77 | PIK3CG (0.43) | PIK3CDPIK3R1PIK3CG | |
| SCHEMBL8166957 | 0.77 | TAS1R3 (0.33) | TAS1R3TAS1R1TAS1R2PIK3CDPIK3R1 | |
| SCHEMBL29099608 | 0.77 | PIK3CG (0.43) | PIK3CDPIK3R1PIK3CG | |
| SCHEMBL4327713 | 0.76 | HTR2A (0.38) | PIK3CDPIK3R1PIK3CGHTR2AHTR2C | |
| SCHEMBL1001568 | 0.75 | PIK3CD (0.42) | TAS1R3TAS1R1TAS1R2PIK3CDPIK3R1 | |
| SCHEMBL4329783 | 0.74 | PIK3CG (0.41) | PIK3CDPIK3R1PIK3CG | |
| SCHEMBL2022710 | 0.74 | TP53 (0.36) | TP53MAPT | |
| SCHEMBL2025050 | 0.73 | PARP1 (0.48) | — | |
| SCHEMBL2022642 | 0.73 | TP53 (0.49) | TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130853-A1 | HYDRAZIDES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 681 | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008130853-A1 | HYDRAZIDES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 681 | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |