Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.79 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.79 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842065 | 0.89 | SCN9A (1.00) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4842078 | 0.89 | SCN9A (1.00) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4841770 | 0.86 | SCN9A (0.80) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4830465 | 0.86 | SCN9A (0.80) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4830458 | 0.86 | SCN9A (0.80) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL7031626 | 0.84 | KCNH2 (0.56) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4788640 | 0.84 | KCNH2 (0.56) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL7031622 | 0.84 | KCNH2 (0.56) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4853268 | 0.84 | SCN9A (0.76) | SCN9ASCN5AKCNH2DRD2DRD3 | |
| SCHEMBL4853281 | 0.84 | SCN9A (0.76) | SCN9ASCN5AKCNH2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |