Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.76 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853268 | 1.00 | SCN9A (0.76) | SCN9AKCNH2SCN5ANPC1HPGD | |
| SCHEMBL4842065 | 0.86 | SCN9A (1.00) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4842078 | 0.86 | SCN9A (1.00) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4830466 | 0.85 | SCN9A (1.00) | SCN9AKCNH2SCN5AHPGDMAPT | |
| SCHEMBL4830475 | 0.85 | SCN9A (1.00) | SCN9AKCNH2SCN5AHPGDMAPT | |
| SCHEMBL4834375 | 0.85 | SCN9A (1.00) | SCN9AKCNH2SCN5AHPGDMAPT | |
| SCHEMBL4748128 | 0.85 | SCN9A (0.75) | SCN9AKCNH2SCN5AALDH1A1DRD2 | |
| SCHEMBL4751189 | 0.84 | SCN9A (0.79) | SCN9AKCNH2SCN5ADRD2HTR2A | |
| SCHEMBL4836383 | 0.84 | SCN9A (0.71) | SCN9AKCNH2SCN5APOLBDRD2 | |
| SCHEMBL8075533 | 0.84 | SCN9A (0.71) | SCN9AKCNH2SCN5AALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |