Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 9/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.43 |
| ▸ | ACACA | Q13085 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2106686 | 1.00 | F11 (0.55) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL2106688 | 1.00 | F11 (0.55) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL3177393 | 0.91 | ATM (0.58) | F11ATMKMT2AMEN1ACACB | |
| SCHEMBL2106191 | 0.90 | F11 (0.69) | F11ATMKMT2AMEN1KLKB1 | |
| SCHEMBL2106189 | 0.90 | F11 (0.69) | F11ATMKMT2AMEN1KLKB1 | |
| SCHEMBL3159727 | 0.89 | ATM (0.56) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL3159697 | 0.89 | ATM (0.56) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL13524378 | 0.89 | ATM (0.56) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL3166877 | 0.89 | ATM (0.56) | F11ATMKMT2AMEN1NPY5R | |
| SCHEMBL2107347 | 0.84 | F11 (0.77) | F11ATMKMT2AMEN1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966141-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070818-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |