Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PER2 | O15055 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978783 | 0.81 | HRH3 (0.55) | HRH3MAPKAPK2RPS6KA3RPS6KA2 | |
| SCHEMBL2986390 | 0.81 | HRH3 (0.55) | HRH3MAPKAPK2RPS6KA3RPS6KA2 | |
| SCHEMBL2978787 | 0.81 | HRH3 (0.55) | HRH3MAPKAPK2RPS6KA3RPS6KA2 | |
| SCHEMBL30954513 | 0.77 | MAPKAPK2 (0.47) | HRH3MAPKAPK2RPS6KA3RPS6KA2ALOX5 | |
| SCHEMBL30954512 | 0.77 | MAPKAPK2 (0.47) | HRH3MAPKAPK2RPS6KA3RPS6KA2ALOX5 | |
| SCHEMBL5318576 | 0.77 | RPS6KA3 (0.41) | HRH3MAPKAPK2RPS6KA3RPS6KA2 | |
| SCHEMBL2971178 | 0.77 | HRH3 (0.56) | HRH3CREBBPALOX5KMT2A | |
| SCHEMBL2971184 | 0.77 | HRH3 (0.56) | HRH3CREBBPALOX5KMT2A | |
| SCHEMBL2973948 | 0.77 | HRH3 (0.56) | HRH3CREBBPALOX5KMT2A | |
| SCHEMBL7396812 | 0.76 | RPS6KA3 (0.43) | HRH3RPS6KA3RPS6KA2KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960401-A1 | TRICYCLIC AMIDE DERIVATIVES USEFUL FOR TREATING OBESITY | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007065820-A1 | TRICYCLIC AMIDE DERIVATIVES USEFUL FOR TREATING OBESITY | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-14 | — | — | WO | disclosed |