Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751756 | 1.00 | DRD4 (0.35) | DRD4HSD11B1GAAHCRTR1HCRTR2 | |
| SCHEMBL4019770 | 0.95 | EED (0.33) | DRD4HSD11B1GAAHCRTR1HCRTR2 | |
| SCHEMBL4019773 | 0.95 | EED (0.33) | DRD4HSD11B1GAAHCRTR1HCRTR2 | |
| SCHEMBL4019242 | 0.87 | KMT2A (0.34) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4024341 | 0.87 | KMT2A (0.34) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4022107 | 0.86 | EED (0.36) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4024177 | 0.86 | EED (0.36) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4779152 | 0.85 | PROKR1 (0.35) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4779147 | 0.85 | PROKR1 (0.35) | DRD4HCRTR1HCRTR2EEDKMT2A | |
| SCHEMBL4020606 | 0.85 | KDM2B (0.40) | GAAKMT2AMEN1ALDH1A1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |