Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779152 | 1.00 | PROKR1 (0.35) | PROKR1DRD4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4019575 | 0.90 | EED (0.37) | PROKR1CYP1A2CYP3A4CYP2C9EED | |
| SCHEMBL4019577 | 0.90 | EED (0.37) | PROKR1CYP1A2CYP3A4CYP2C9EED | |
| SCHEMBL4019987 | 0.87 | KMT2A (0.39) | DRD4EEDMEN1KMT2ACCR5 | |
| SCHEMBL4019982 | 0.87 | KMT2A (0.39) | DRD4EEDMEN1KMT2ACCR5 | |
| SCHEMBL4029251 | 0.86 | DRD4 (0.37) | PROKR1DRD4CYP1A2CYP3A4KMT2A | |
| SCHEMBL4029254 | 0.86 | DRD4 (0.37) | PROKR1DRD4CYP1A2CYP3A4KMT2A | |
| SCHEMBL4020739 | 0.86 | PROKR1 (0.38) | PROKR1DRD4KMT2AOPRM1OPRL1 | |
| SCHEMBL4020735 | 0.86 | PROKR1 (0.38) | PROKR1DRD4KMT2AOPRM1OPRL1 | |
| SCHEMBL4751758 | 0.85 | DRD4 (0.35) | DRD4EEDMEN1KMT2AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962846-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007059323-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-24 | — | — | WO | claimed |