Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19932072 | 0.84 | EGFR (0.57) | AURKBEGFRSUV39H2MEN1KMT2A | |
| SCHEMBL4697286 | 0.82 | AURKB (0.53) | AURKBEGFRSUV39H2MEN1KMT2A | |
| SCHEMBL19931816 | 0.80 | AURKB (0.52) | AURKBEGFRSUV39H2MEN1KMT2A | |
| SCHEMBL4697831 | 0.79 | AURKB (0.57) | AURKBEGFRCA1CA2SUV39H2 | |
| SCHEMBL8693590 | 0.78 | CA1 (0.54) | AURKBEGFRCA1CA2SUV39H2 | |
| SCHEMBL10862149 | 0.78 | EGFR (0.52) | AURKBEGFRCA1CA2SUV39H2 | |
| SCHEMBL26967653 | 0.76 | CA1 (0.46) | AURKBEGFRCA1CA2MEN1 | |
| SCHEMBL2472278 | 0.76 | MAPK1 (0.57) | AURKBEGFRCA1CA2SUV39H2 | |
| SCHEMBL3218237 | 0.74 | CA1 (0.48) | AURKBEGFRCA1CA2SUV39H2 | |
| SCHEMBL6815605 | 0.74 | F13A1 (0.47) | CA1CA2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966222-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007059341-A2 | PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-05-24 | — | — | WO | disclosed |