SCHEMBL3218237

SCHEMBL3218237

CC(C)(C)OC(=O)NCC(=O)Nc1ccc(CO)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
NAMPT P43490 3/20 0.47
CYP17A1 P05093 1/20 0.47
HDAC3 O15379 2/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
PTPN11 Q06124 1/20 0.46
TLR7 Q9NYK1 1/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
AURKB Q96GD4 3/20 0.44
EGFR P00533 2/20 0.44
RAF1 P04049 1/20 0.44
KDR P35968 1/20 0.44
MAP2K2 P36507 1/20 0.44
MAP2K1 Q02750 1/20 0.44
MAPT P10636 1/20 0.44
TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30483102 0.97 CA1 (0.46) CA1CA2NAMPTCYP17A1HDAC3
SCHEMBL8693590 0.91 CA1 (0.54) CA1CA2NAMPTCYP17A1HDAC3
SCHEMBL15295619 0.89 NAMPT (0.49) CA1CA2NAMPTCYP17A1HDAC3
SCHEMBL17874907 0.86 HPGD (0.50) CA1CA2NAMPTCYP17A1HDAC3
SCHEMBL10850707 0.85 CA1 (0.50) CA1CA2NAMPTCYP17A1HDAC3
SCHEMBL14679376 0.85 POLB (0.54) CA1CA2HDAC3HDAC1HDAC10
SCHEMBL10845806 0.85 POLB (0.53) CA1CA2NAMPTHDAC3HDAC1
SCHEMBL7722182 0.85 CYP17A1 (0.53) CA1CA2NAMPTCYP17A1PTPN11
SCHEMBL245094 0.85 CYP17A1 (0.61) CA1NAMPTCYP17A1HDAC3PTPN11
SCHEMBL400342 0.84 CA1 (0.49) CA1CA2NAMPTCYP17A1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD THERAPEUTICS LIMITED (CN) 2024-08-15 US disclosed
US-20240066133-A1 THERAPEUTIC AGENTS AND CONJUGATES THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2024-02-29 US disclosed
US-20240066133-A1 THERAPEUTIC AGENTS AND CONJUGATES THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2024-02-29 US disclosed
US-20240066133-A1 THERAPEUTIC AGENTS AND CONJUGATES THEREOF AJ SCIENCES (YIXING) CO., LTD (CN) 2024-02-29 US disclosed
EP-4313154-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF OD Therapeutics Limited (HK) 2024-02-07 EP disclosed
WO-2024020379-A2 PRODRUGS, PRODRUG COMPOSITIONS AND RELATED METHODS PRAESIDIA BIOTHERAPEUTICS INC. (US) 2024-01-25 WO disclosed
CN-117355337-A Protein-macromolecule conjugates and methods of use thereof 奥迪曼药业科技有限公司 2024-01-05 CN disclosed
EP-4114417-A2 THERAPEUTIC AGENTS AND CONJUGATES THEREOF Beijing Xuanyi Pharmasciences Co., Ltd. (CN) 2023-01-11 EP disclosed
WO-2022212362-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2022-10-06 WO disclosed
WO-2021178818-A2 THERAPEUTIC AGENTS AND CONJUGATES THEREOF BEIJING XUANYI PHARMASCIENCES CO., LTD. (CN) 2021-09-10 WO disclosed
WO-2018143145-A1 METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM 中外製薬株式会社 2018-08-09 WO disclosed
WO-2017147146-A1 PRODRUGS OF PHENOLIC TRPV1 AGONISTS Concentric Analgesics, Inc. (US) 2017-08-31 WO disclosed
US-8962674-B2 Curcumin derivative TOKYO INSTITUTE OF TECHNOLOGY (JP) 2015-02-24 US disclosed
US-20130280204-A1 Polymer-Attached Inhibitors of Influenza Virus NATIONAL INSTITUTES OF HEALTH 2013-10-24 US disclosed
US-20100048901-A1 NOVEL CURCUMIN DERIVATIVE TOKYO INSTITUTE OF TECHNOLOGY (JP) 2010-02-25 US disclosed
EP-2123637-A1 NOVEL CURCUMIN DERIVATIVE Tokyo Institute of Technology (JP) 2009-11-25 EP disclosed
US-7371755-B1 Antiviral agents BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) 2008-05-13 US disclosed
EP-1214317-A1 ANTIVIRAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 2002-06-19 EP disclosed
WO-2001019822-A1 ANTIVIRAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2001-03-22 WO disclosed
US-5571836-A NEURAMINIC ACID DERIVATIVES BOVIN NICOLAI V (RU) 1996-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048901-A1 NOVEL CURCUMIN DERIVATIVE BACE1, APP, BACE2 CA1 271/4885CA2 1240/4885NAMPT 2124/4885
US-20240269293-A1 PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF CD44, MACROD1, MSN CA1 3853/4885CA2 4805/4885NAMPT 2205/4885
US-20130280204-A1 Polymer-Attached Inhibitors of Influenza Virus PARG, PARN, SARS1 CA1 967/4885CA2 3158/4885NAMPT 1110/4885
US-20240066133-A1 THERAPEUTIC AGENTS AND CONJUGATES THEREOF TLR9, STING1, TLR3 CA1 3710/4885CA2 2073/4885NAMPT 3461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.