Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.65 |
| ▸ | MTOR | P42345 | 3/20 | 0.65 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.65 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731865 | 0.91 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL730000 | 0.89 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL729543 | 0.88 | PIK3CD (0.82) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL729613 | 0.86 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL729763 | 0.86 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL729583 | 0.86 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL731923 | 0.83 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL25494702 | 0.83 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL624445 | 0.82 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL25495064 | 0.81 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |