Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578113 | 1.00 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2HTTHIF1A | |
| SCHEMBL3578116 | 1.00 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2HTTHIF1A | |
| SCHEMBL4997128 | 0.90 | PDGFRB (0.49) | RAB9ANPC1SMN1; SMN2HTTHIF1A | |
| SCHEMBL4997124 | 0.90 | PDGFRB (0.49) | RAB9ANPC1SMN1; SMN2HTTHIF1A | |
| SCHEMBL13344352 | 0.90 | PSD (0.43) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 | |
| SCHEMBL3571650 | 0.90 | PSD (0.43) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 | |
| SCHEMBL3571648 | 0.90 | PSD (0.43) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 | |
| SCHEMBL3563836 | 0.89 | PSD (0.42) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 | |
| SCHEMBL3570773 | 0.89 | PSD (0.42) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 | |
| SCHEMBL3570771 | 0.89 | PSD (0.42) | SMN1; SMN2PARP1HRH3ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963273-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075783-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITOR | WYETH (US) | 2007-07-05 | — | — | WO | disclosed |