Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 4/20 | 1.00 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 11/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.72 |
| ▸ | RAB9A | P51151 | 10/20 | 0.72 |
| ▸ | NPC1 | O15118 | 8/20 | 0.72 |
| ▸ | HTT | P42858 | 8/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | STAT3 | P40763 | 1/20 | 0.72 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.68 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.68 |
| ▸ | GFER | P55789 | 2/20 | 0.68 |
| ▸ | INSR | P06213 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 4/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4752507 | 1.00 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL14180797 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL10847207 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL10845067 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL10847205 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL10845065 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| SCHEMBL14180800 | 0.99 | KDM4A (1.00) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| Bromide SCHEMBL10843057 | 0.97 | KDM4A (0.97) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| Bromide SCHEMBL10845380 | 0.97 | KDM4A (0.97) | KDM4AKDM2AMEN1KMT2ARAB9A | |
| Bromide SCHEMBL10845383 | 0.97 | KDM4A (0.97) | KDM4AKDM2AMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154008-A1 | METHODS AND COMPOSITIONS FOR INHIBITING TOLL-LIKE RECEPTOR MEDIATED IMMUNE RESPONSES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-18 | — | — | WO | claimed |
| EP-3630779-B1 | ANTIBIOTIC RESISTANCE BREAKERS | KING S COLLEGE LONDON (GB) | 2025-09-03 | — | — | EP | disclosed |
| US-11746116-B2 | Antibiotic resistance breakers | KING'S COLLEGE LONDON (GB) | 2023-09-05 | — | — | US | disclosed |
| CN-110869373-B | Antibiotic resistance disruptors | 伦敦皇家学院 | 2023-03-07 | — | — | CN | disclosed |
| EP-3366302-B1 | PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENERATION AND INHIBITORS FOR PROTECTING CELLS | UNIV KENTUCKY RES FOUND (US) | 2021-12-08 | — | — | EP | disclosed |
| EP-3366302-A1 | PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENERATION AND INHIBITORS FOR PROTECTING CELLS | University Of Kentucky Research Foundation (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-2734240-B1 | PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENEREATION AND INHIBITORS FOR PROTECTING CELLS | UNIV KENTUCKY RES FOUND (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2008154008-A1 | METHODS AND COMPOSITIONS FOR INHIBITING TOLL-LIKE RECEPTOR MEDIATED IMMUNE RESPONSES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11746116-B2 | Antibiotic resistance breakers | ABCC1, ARL1, AKR1C3 | ACHE 1572/4885KDM4A 2593/4885KDM2A 3472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.