Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4830101 | 0.76 | CA12 (0.50) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL15308528 | 0.76 | ADORA1 (0.41) | SMN1; SMN2MAPTCA12CA1CA2 | |
| SCHEMBL9080409 | 0.76 | TSHR (0.43) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL16048994 | 0.74 | ADORA1 (0.40) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL16079405 | 0.74 | ADORA1 (0.40) | SMN1; SMN2MAPTCA12CA1CA2 | |
| SCHEMBL5571616 | 0.73 | POLB (0.38) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL8189712 | 0.72 | TSHR (0.56) | MAPTLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL25620998 | 0.72 | CA12 (0.49) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL21428169 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL4754352 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |