Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750915 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL25620998 | 0.73 | CA12 (0.49) | SMN1; SMN2ALDH1A1KMT2APOLBHPGD | |
| SCHEMBL1627475 | 0.73 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL25258780 | 0.71 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL7008915 | 0.71 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL4752944 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KMT2APOLBHPGD | |
| SCHEMBL25295408 | 0.70 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL25258164 | 0.70 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL25294601 | 0.70 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R | |
| SCHEMBL4862480 | 0.70 | IGF1R (0.39) | SMN1; SMN2ALDH1A1KMT2APOLBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008145398-A1 | 4-ARYLPYRROLE SUBSTITUTED 2-INDOLINE DERIVATIVES ACTIVE AS PROTEIN KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2008-12-04 | — | — | WO | disclosed |