Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18083219 | 0.90 | L3MBTL1 (0.50) | L3MBTL1KCNH2GAAMAPTDRD4 | |
| SCHEMBL12601973 | 0.88 | GAA (0.40) | L3MBTL1KCNH2GAAMAPTKMT2A | |
| SCHEMBL23080822 | 0.84 | GAA (0.39) | L3MBTL1KCNH2GAAMAPTKMT2A | |
| SCHEMBL12181571 | 0.83 | L3MBTL1 (0.52) | L3MBTL1KCNH2MAPTDRD4ALDH1A1 | |
| SCHEMBL4707312 | 0.83 | L3MBTL1 (0.41) | L3MBTL1KCNH2MAPTDRD4PIK3CD | |
| SCHEMBL17000243 | 0.82 | L3MBTL1 (0.44) | L3MBTL1KCNH2DRD4PIK3CDPIP5K1C | |
| SCHEMBL12311437 | 0.82 | L3MBTL1 (0.55) | L3MBTL1KCNH2MAPTDRD4ALDH1A1 | |
| SCHEMBL2701043 | 0.80 | L3MBTL1 (0.49) | L3MBTL1KCNH2MAPTDRD4ALDH1A1 | |
| SCHEMBL17493853 | 0.80 | KCNH2 (0.43) | KCNH2GAAMAPTKMT2AALDH1A1 | |
| SCHEMBL7992278 | 0.80 | L3MBTL1 (0.49) | L3MBTL1KCNH2MAPTDRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966141-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070818-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |