Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 6/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 5/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022855 | 0.90 | AXL (0.51) | AXLMAP3K7IRAK4SRCEPHB4 | |
| SCHEMBL4749275 | 0.88 | ABL1 (0.39) | AXLSRCEPHB4JAK2JAK3 | |
| SCHEMBL4752216 | 0.84 | IGF1R (0.39) | SRCEPHB4JAK2JAK3SYK | |
| SCHEMBL14023511 | 0.78 | ABL1 (0.40) | AXLJAK1JAK2JAK3FLT3 | |
| SCHEMBL4751809 | 0.77 | ABL1 (0.42) | AXLJAK2JAK3RETBRAF | |
| SCHEMBL1098622 | 0.75 | ABL1 (0.40) | AXLJAK1JAK2JAK3FLT3 | |
| SCHEMBL14022857 | 0.74 | IGF1R (0.40) | AXLSRCJAK2JAK3RET | |
| SCHEMBL1098894 | 0.74 | SYK (0.40) | AXLJAK1JAK2JAK3FLT3 | |
| SCHEMBL1098407 | 0.74 | ABL1 (0.43) | AXLSRCJAK2JAK3RET | |
| SCHEMBL18532076 | 0.74 | ABL1 (0.39) | AXLJAK1JAK2JAK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |