Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | BCR | P11274 | 3/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749275 | 0.96 | ABL1 (0.39) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL14022857 | 0.89 | IGF1R (0.40) | IGF1RSYKEHMT2EHMT1IKBKE | |
| SCHEMBL4751809 | 0.85 | ABL1 (0.42) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL14023511 | 0.85 | ABL1 (0.40) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL4752976 | 0.84 | AXL (0.46) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL1098407 | 0.82 | ABL1 (0.43) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL1108273 | 0.82 | AIMP2 (0.47) | SYKABL1BCREGFRCDK2 | |
| SCHEMBL1098622 | 0.82 | ABL1 (0.40) | IGF1RSYKIKBKETBK1ABL1 | |
| SCHEMBL4753008 | 0.82 | CCNA2 (0.47) | SYKCDK2 | |
| SCHEMBL14023524 | 0.81 | RET (0.38) | IGF1RSYKABL1BCRPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008140419-A2 | PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD (SG) | 2008-11-20 | — | — | WO | disclosed |