Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.58 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329517 | 0.87 | MEN1 (0.65) | MAOBALDH1A1USP2LMNANPSR1 | |
| SCHEMBL27406495 | 0.86 | ALDH1A1 (0.66) | MAOBALDH1A1USP2LMNANPSR1 | |
| SCHEMBL31351172 | 0.86 | ALDH1A1 (0.66) | MAOBALDH1A1USP2LMNANPSR1 | |
| SCHEMBL4750736 | 0.86 | USP2 (0.81) | MAOBALDH1A1USP2LMNANPSR1 | |
| SCHEMBL14427604 | 0.85 | ALDH1A1 (0.63) | ALDH1A1LMNAL3MBTL1PKMHPGD | |
| SCHEMBL27405224 | 0.84 | MAOB (0.60) | MAOBALDH1A1USP2LMNANPSR1 | |
| SCHEMBL13503924 | 0.84 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1PKMHPGDMEN1 | |
| SCHEMBL4754213 | 0.83 | MAOB (0.74) | MAOBALDH1A1USP2NPSR1CYP3A4 | |
| SCHEMBL4753324 | 0.82 | MAOB (0.64) | MAOBALDH1A1USP2LMNACYP3A4 | |
| SCHEMBL31350986 | 0.82 | MAOB (1.00) | MAOBALDH1A1USP2NPSR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |