Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757272 | 0.85 | KDM4E (0.40) | KDM4EBACE1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL18886864 | 0.77 | BACE1 (0.41) | KDM4EBACE1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL521935 | 0.74 | NQO2 (0.46) | KDM4EKMT2ACYP1A2SMN1; SMN2MAPT | |
| SCHEMBL2407443 | 0.73 | KDM4E (0.44) | KDM4EBACE1KMT2ACYP1A2MPO | |
| SCHEMBL12638658 | 0.69 | KDM4E (0.57) | KDM4EBACE1KMT2ACYP1A2MPO | |
| SCHEMBL209493 | 0.68 | KDM4E (0.38) | KDM4EBACE1KMT2APDGFRBPDGFRA | |
| SCHEMBL26666976 | 0.68 | KDM4E (0.35) | KDM4EBACE1KMT2AMPOMAPK14 | |
| SCHEMBL1193454 | 0.67 | CYP1A2 (0.61) | KDM4ECYP1A2LMNAPOLB | |
| SCHEMBL30081474 | 0.67 | CYP1A2 (0.61) | KDM4ECYP1A2LMNAPOLB | |
| SCHEMBL406789 | 0.67 | BACE1 (0.41) | KDM4EBACE1KMT2APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154905-A2 | MODIFICATIONS OF THE HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID | SCHEBO BIOTECH AG (DE) | 2008-12-24 | — | — | WO | disclosed |