Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450767 | 0.78 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL1509392 | 0.77 | SCN4A (0.43) | SLC6A4KMT2ALMNACYP2D6HTR2C | |
| SCHEMBL5958191 | 0.76 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL6048337 | 0.75 | SLC7A5 (0.51) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL16012833 | 0.74 | ACACB (0.33) | CYP2C9TSHR | |
| SCHEMBL11511000 | 0.74 | KCNA3 (0.37) | SLC6A4HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL8095037 | 0.74 | HTR2C (0.40) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL20912965 | 0.74 | HTR2C (0.40) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL4452437 | 0.74 | PBRM1 (0.35) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL8505129 | 0.73 | KCNA3 (0.40) | SLC6A4HRH3DRD2SLC7A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | claimed |
| WO-2008150231-A1 | NEW HETEROCYCLIC COMPOUNDS FOR TREATMENT OF RESPIRATORY, AIRWAY OR INFLAMMATORY DISORDERS | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | WO | disclosed |