Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | KIF5B | P33176 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | ETV6 | P41212 | 5/20 | 0.41 |
| ▸ | CCDC6 | Q16204 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167662 | 0.88 | FYN (0.59) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4695327 | 0.79 | RET (0.43) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4757041 | 0.77 | FYN (0.53) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4695372 | 0.76 | RET (0.55) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4173163 | 0.76 | FYN (0.47) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4178858 | 0.73 | FYN (0.57) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4695093 | 0.73 | FYN (0.68) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4171927 | 0.72 | FYN (0.67) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4756311 | 0.70 | RET (0.47) | FYNRETKIF5BKDRETV6 | |
| SCHEMBL4179850 | 0.69 | FYN (0.71) | FYNRETKIF5BKDRETV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993552-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103432-A9 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2008-01-10 | — | — | WO | disclosed |
| WO-2007103432-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2007-09-13 | — | — | WO | disclosed |