Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.50 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243543 | 0.88 | PDPK1 (0.46) | TRPC3ORAI1KDM4EL3MBTL1PTGS2 | |
| SCHEMBL31625145 | 0.87 | KLKB1 (0.48) | KLKB1TRPC3ORAI1PTGS2PTGS1 | |
| SCHEMBL31625143 | 0.87 | KLKB1 (0.48) | KLKB1TRPC3ORAI1PTGS2PTGS1 | |
| SCHEMBL3558495 | 0.84 | PTGS2 (0.56) | TRPC3ORAI1KDM4EL3MBTL1PTGS2 | |
| SCHEMBL18865512 | 0.83 | KLKB1 (0.49) | KLKB1ORAI1PTGS2PTGS1STIM1 | |
| SCHEMBL18865505 | 0.83 | CYP1A2 (0.44) | KLKB1TRPC3KDM4EPTGS2PTGS1 | |
| SCHEMBL3277337 | 0.82 | PTGS2 (0.55) | TRPC3ORAI1KDM4EL3MBTL1PTGS2 | |
| SCHEMBL31546278 | 0.81 | PTGS2 (0.50) | KLKB1PTGS2PTGS1PDPK1CYP2C9 | |
| Hydrochloric Acid SCHEMBL27618956 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1PDPK1CYP2C9 | |
| SCHEMBL18865753 | 0.80 | PTGS2 (0.49) | KLKB1PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148836-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008148836-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |