Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755031 | 1.00 | KDM4E (0.61) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL15130630 | 0.82 | KDM4E (0.91) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4155399 | 0.82 | KDM4E (0.38) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4155397 | 0.82 | KDM4E (0.38) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4140069 | 0.82 | KDM4E (0.38) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4140062 | 0.82 | KDM4E (0.38) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4143220 | 0.81 | MAPT (0.45) | KDM4EHTTATMMAPTALDH1A1 | |
| SCHEMBL4152953 | 0.80 | KDM4E (0.37) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL4152956 | 0.80 | KDM4E (0.37) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL4795076 | 0.80 | ALDH1A1 (0.38) | KDM4EHTTATMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000818-A1 | 3-CARBONYLAMINOTHIOPHENE-2-CARBOXYLIC ACIDS AS HEPATITIS C VIRUS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-31 | — | — | WO | disclosed |