Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554708 | 0.79 | NPSR1 (0.55) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL124863 | 0.79 | NPSR1 (0.55) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL10254937 | 0.78 | NPC1 (0.50) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL7746477 | 0.76 | NPC1 (0.49) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL12426069 | 0.76 | NPC1 (0.56) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL19823669 | 0.76 | NPC1 (0.54) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL16071071 | 0.76 | NPC1 (0.51) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL7636834 | 0.76 | NPSR1 (0.52) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL6361487 | 0.75 | PTGES (0.50) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL15600987 | 0.74 | UTS2R (0.50) | NPC1RAB9AMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968958-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007079961-A1 | SUBSTITUTED THIAZOLES AND THEIR USE FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |