Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 10/20 | 0.42 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL475608 | 0.86 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| SCHEMBL475393 | 0.86 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| SCHEMBL475541 | 0.86 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| Hydrochloric Acid SCHEMBL1748959 | 0.85 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| Hydrochloric Acid SCHEMBL1748452 | 0.85 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| Hydrochloric Acid SCHEMBL1748451 | 0.85 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2HTR6CNR1CTSL | |
| SCHEMBL475388 | 0.80 | HPGD (0.46) | HPGDSMN1; SMN2SOS1HTR6CNR1 | |
| Hydrochloric Acid SCHEMBL1748277 | 0.80 | HPGD (0.46) | HPGDSMN1; SMN2SOS1HTR6CNR1 | |
| SCHEMBL475403 | 0.79 | ADRB1 (0.45) | HPGDSMN1; SMN2SOS1HTR6CNR1 | |
| SCHEMBL475613 | 0.79 | ADRB1 (0.48) | HPGDSMN1; SMN2SOS1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-B1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | GALENEA CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |