Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755038 | 0.95 | TRPV1 (0.37) | TRPV1MAPK1CYP3A4CYP2C9NTRK1 | |
| SCHEMBL13983099 | 0.90 | TRPV1 (0.37) | TRPV1SYKBRD9NTRK1SMN1; SMN2 | |
| SCHEMBL13983135 | 0.88 | TRPV1 (0.37) | TRPV1CYP3A4CYP2C9BRD9NTRK1 | |
| SCHEMBL13983104 | 0.85 | TRPV1 (0.38) | TRPV1MAPK1NTRK1CNR2 | |
| SCHEMBL13983272 | 0.83 | TP53 (0.33) | SYKP2RX7 | |
| SCHEMBL13983521 | 0.82 | SLC9A3 (0.34) | TRPV1MAPK1SYKBRD9SMN1; SMN2 | |
| SCHEMBL13983280 | 0.81 | BRD9 (0.33) | CYP3A4CYP2C9BRD9 | |
| SCHEMBL4755426 | 0.80 | MAPK1 (0.36) | TRPV1MAPK1CYP3A4CYP2C9NTRK1 | |
| SCHEMBL13983271 | 0.78 | — | — | |
| SCHEMBL13983252 | 0.73 | TRPV1 (0.37) | TRPV1MAPK1NTRK1SMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151927-A2 | 6-N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | NYCOMED GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |