Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444045 | 0.80 | MEN1 (0.32) | MEN1ALDH1A1MAPTNPY1RMAPK1 | |
| SCHEMBL4756834 | 0.80 | HTT (0.36) | MEN1ALDH1A1MAPTNPY1RMAPK1 | |
| SCHEMBL7151799 | 0.72 | — | — | |
| SCHEMBL11765884 | 0.72 | ALDH1A1 (0.33) | ALDH1A1MAPK1 | |
| SCHEMBL5153626 | 0.72 | — | — | |
| SCHEMBL10687515 | 0.70 | ALDH1A1 (0.35) | MEN1ALDH1A1MAPTNPY1RMAPK1 | |
| SCHEMBL164493 | 0.68 | — | — | |
| SCHEMBL14293144 | 0.68 | — | — | |
| SCHEMBL11746174 | 0.64 | ALDH1A1 (0.43) | MEN1ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL8441639 | 0.64 | HTT (0.34) | MEN1ALDH1A1MAPTNPY1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |