Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PER2 | O15055 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751863 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL4751862 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL3751311 | 0.94 | HSD11B1 (0.44) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL3748660 | 0.94 | HSD11B1 (0.44) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL3741941 | 0.85 | HSD11B1 (0.57) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL13046388 | 0.81 | HSD11B1 (0.34) | HSD11B1HRH3LOXL2RAB9ANPC1 | |
| SCHEMBL4696813 | 0.78 | HSD11B1 (0.40) | HSD11B1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4696816 | 0.78 | HSD11B1 (0.40) | HSD11B1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4696662 | 0.73 | HSD11B1 (0.42) | HSD11B1SMN1; SMN2ALDH1A1HPGDPER2 | |
| SCHEMBL4697992 | 0.73 | HSD11B1 (0.42) | HSD11B1SMN1; SMN2ALDH1A1HPGDPER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830840-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2008-07-16 | — | — | EP | claimed |