Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614351 | 0.81 | BRPF1 (0.55) | PDE3BPDE3AMKNK2CDC7CDK2 | |
| SCHEMBL30066887 | 0.81 | BRPF1 (0.55) | PDE3BPDE3AMKNK2CDC7CDK2 | |
| SCHEMBL29070088 | 0.77 | PDE3B (0.39) | DAOPDE3BPDE3AMKNK2CDC7 | |
| SCHEMBL29981364 | 0.77 | PDE3B (0.39) | DAOPDE3BPDE3AMKNK2CDC7 | |
| SCHEMBL17910206 | 0.73 | CDK4 (0.36) | PDE3BPDE3AMKNK2CDC7CDK2 | |
| SCHEMBL29830392 | 0.73 | CDK4 (0.51) | CDK2MAPK9MAPK10HDAC1HDAC6 | |
| SCHEMBL29830247 | 0.73 | USP2 (0.43) | PDE3BPDE3ACDK2MAPK9MAPK10 | |
| SCHEMBL10245183 | 0.73 | CDK4 (0.51) | CDK2MAPK9MAPK10HDAC1HDAC6 | |
| SCHEMBL26815266 | 0.73 | USP2 (0.43) | PDE3BPDE3ACDK2MAPK9MAPK10 | |
| SCHEMBL12604116 | 0.73 | PDE3B (0.36) | PDE3BPDE3AMKNK2CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996553-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | Avanir Pharmaceuticals (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109251-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-09-27 | — | — | WO | disclosed |