Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667045 | 0.88 | IDO1 (0.47) | IDO1PDPK1 | |
| SCHEMBL30056716 | 0.79 | IDO1 (0.53) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL4248158 | 0.79 | IDO1 (0.53) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL59025 | 0.75 | IDO1 (0.53) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL10729425 | 0.75 | IDO1 (0.53) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL29357487 | 0.74 | IDO1 (0.57) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL145977 | 0.74 | IDO1 (0.57) | IDO1ADRA2AADRA1ACYP2D6LMNA | |
| SCHEMBL16242534 | 0.74 | MAOB (0.47) | — | |
| SCHEMBL15340730 | 0.73 | IDO1 (0.44) | IDO1ALDH1A1MEN1KMT2APDPK1 | |
| SCHEMBL13082165 | 0.72 | IDO1 (0.55) | IDO1ADRA2AADRA1ACYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976843-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |