Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056716 | 1.00 | IDO1 (0.53) | IDO1TSHRADRA2AADRA1ACYP2D6 | |
| SCHEMBL9776721 | 0.86 | IDO1 (0.50) | IDO1PDPK1 | |
| SCHEMBL29458344 | 0.86 | IDO1 (0.50) | IDO1PDPK1 | |
| SCHEMBL17057925 | 0.86 | IDO1 (0.50) | IDO1PDPK1 | |
| Hydrochloric Acid SCHEMBL10524447 | 0.86 | IDO1 (0.45) | IDO1TSHRLMNAHTTALDH1A1 | |
| SCHEMBL4756410 | 0.79 | IDO1 (0.50) | IDO1TSHRADRA2AADRA1ACYP2D6 | |
| SCHEMBL29357487 | 0.77 | IDO1 (0.57) | IDO1TSHRADRA2AADRA1ACYP2D6 | |
| SCHEMBL145977 | 0.77 | IDO1 (0.57) | IDO1TSHRADRA2AADRA1ACYP2D6 | |
| SCHEMBL13082165 | 0.76 | IDO1 (0.55) | IDO1TSHRADRA2AADRA1ACYP2D6 | |
| SCHEMBL1105071 | 0.74 | IDO1 (0.53) | IDO1TSHRADRA2AADRA1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107304267-B | Polypropylene powder and its preparation for selective laser sintering | 中国石油化工股份有限公司 | 2019-11-12 | — | — | CN | claimed |
| CN-109589684-A | A kind of fresh air system electret nanofiber filtration material and preparation method thereof | 嘉兴富瑞邦新材料科技有限公司 | 2019-04-09 | — | — | CN | claimed |
| CN-109589685-A | A kind of automobile air conditioner filter element electret nanofiber filtration material and preparation method thereof | 嘉兴富瑞邦新材料科技有限公司 | 2019-04-09 | — | — | CN | claimed |
| CN-109569092-A | A kind of HVAC electret nanofiber filtration material and preparation method thereof | 嘉兴富瑞邦新材料科技有限公司 | 2019-04-05 | — | — | CN | claimed |
| CN-109364579-A | A kind of air purifier electret nanofiber filtration material and preparation method thereof | 嘉兴富瑞邦新材料科技有限公司 | 2019-02-22 | — | — | CN | claimed |
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | ARCUS BIOSCIENCES, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-20230021476-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2023-01-26 | — | — | US | disclosed |
| EP-4121409-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-115298165-A | Tetralin and tetrahydroquinoline compounds as HIF-2 alpha inhibitors | 艾库斯生物科学有限公司 | 2022-11-04 | — | — | CN | disclosed |
| US-20210317079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. | 2021-10-14 | — | — | US | disclosed |
| WO-2021188769-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| EP-3630759-A1 | ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT | Centre National De La Recherche Scientifique (FR) | 2020-04-08 | — | — | EP | disclosed |
| US-20090030228-A1 | Process for producing fluoro-compounds | TOSOH F-TECH, INC. (JP) | 2009-01-29 | — | — | US | disclosed |
| EP-1903021-A1 | PROCESS FOR PRODUCTION OF FLUOROCOMPOUNDS | Tosoh F-Tech, Inc. (JP) | 2008-03-26 | — | — | EP | disclosed |
| JP-2005200366-A | METHOD FOR PRODUCING TETRAHYDRONAPHTHALENE AND NAPHTHALENE DERIVATIVE, AND PRODUCTION INTERMEDIATE | DAINIPPON INK & CHEM INC | 2005-07-28 | — | — | JP | disclosed |
| EP-1191008-B1 | COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME | DAINIPPON INK & CHEMICALS (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6746728-B1 | SUPERIOR LIQUID CRYSTALLINITY AND CO-SOLUBILITY WITH CURRENTLY USED LIQUID CRYSTAL COMPOUNDS; TEMPERATURE RANGE OVER WHICH LIQUID CRYSTALLINITY IS SHOWN IS BROAD; THRESHOLD VOLTAGE IS LOW; CAPABLE OF HIGH SPEED RESPONSE | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2004-06-08 | — | — | US | disclosed |
| EP-1191008-A1 | COMPOUND HAVING TETRAHYDRONAPHTHALENE SKELETON AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2002-03-27 | — | — | EP | disclosed |
| JP-2002003416-A | METHOD FOR PRODUCING 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVE | DAINIPPON INK & CHEM INC | 2002-01-09 | — | — | JP | disclosed |
| JP-2001354601-A | METHOD FOR MANUFACTURING FLUOROTETRAHYDRONAPHTHALENE DERIVATIVE | DAINIPPON INK & CHEM INC | 2001-12-25 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | HIF1AN, HIF1A, EGLN2 | IDO1 720/4885TSHR 3265/4885ADRA2A 2462/4885 |
| US-20230021476-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | IDO1 720/4885TSHR 3265/4885ADRA2A 2462/4885 |
| US-20210317079-A1 | TETRALIN AND TETRAHYDROQUINOLINE COMPOUNDS AS INHIBITORS OF HIF-2ALPHA | HIF1AN, HIF1A, EGLN2 | IDO1 720/4885TSHR 3265/4885ADRA2A 2462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.