Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.60 |
| ▸ | PDE4A | P27815 | 7/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698806 | 0.80 | PDE4A (0.69) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL4699354 | 0.77 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL4702946 | 0.76 | PDE4A (0.67) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL4697930 | 0.75 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL4702655 | 0.75 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL4699784 | 0.74 | PDE4A (0.80) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL155477 | 0.74 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL92611 | 0.74 | PDE4A (0.71) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL450642 | 0.74 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL30074719 | 0.74 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | claimed |